1.ANTIBACTERIAL ACTIVITY OF HERBAL EXTRACTS AGAINST MULTI DRUG RESISTANT STRAINS OF BACTERIA FROM CLINICAL ORIGIN BY 1 T.A.IBRAHIM, 2 B.O. OPAWALE AND 3 J.M.A.OYINLOYE
Abstract
In-vitro antibacterial activity of ethanolic extracts of selected commonly used herbal plants,
Ocimum gratissimum, Vernonia amygdalina, Zingiber officinale and Myristica fragrans were
screened against multi drug resistant bacteria including Staphylococcus aureus, Proteus vulgaris,
Bacillus subtilis, Salmonella typhimurium, Klebsiella pneumoniae and Pseudomonas aeruginosa
of clinical origin by agar well diffusion method. The crude extracts of the plants were fairly
effective against the bacterial isolates as shown by the values of the extracts with concentration
ranging between 50 to 200mg/ml for Ocimum gratissimum and Myristica fragrans and 100 to
200mg/ml for Vernonia amygdalina and Zingiber officiale. The potency of these extracts based
on their zones of inhibition (mm) and MIC values were higher in Myristica fragrans and
Ocimum gratissimum which concludes that their extracts can be used against multi drug
resistance bacteria capable of causing both nosocomial and community acquired infections.
KEY WORDS: Multidrug resistant, Antibiotics, Herbal extracts, Bacteria.
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