4. SOLID PHASE SYNTHESIS OF BENZO[D]THIAZOL-2-YLCARBAMODITHIOATES AND THEIR EVALUATION AS POTENTIAL ANTIFUNGALS by SUMAN R GHATELWAL1, ANJALI SIDHU1, KHUSHBU GUMBER1 AND VINEET K SHARMA2Benzo[d]thiazol-2-amines (1 and 2) were synthesized by bromocyclizati

Authors

  • SUMAN R GHATELWAL1, ANJALI SIDHU1 KHUSHBU GUMBER1 AND VINEET K SHARMA2

Abstract

Benzo[d]thiazol-2-amines (1 and 2) were synthesized by bromocyclization of anilines and potassium thiocyanate. They were further treated with carbon disulphide and alkyl halide over basic aluminum to yield required benzo[d]thiazol-2-ylcarbamodithioates (3-8). The synthesized compounds were characterized on the basis of spectral analysis and screened for in vitro antifungal potential against Pyricularia grisea, Drechslera oryzae, Fusarium moniliforme and Ustilaginoidea virens by spore germination inhibition method. The results were presented in the terms of EC50 values. The compound 3 showed the high fungitoxicity with EC50 values comparable to standard fungicides against most of the test fungi.
KEYWORDS: Benzo[d]thiazoles; Carbamodithioates; Antifungal activity.

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Author Biography

SUMAN R GHATELWAL1, ANJALI SIDHU1 KHUSHBU GUMBER1 AND VINEET K SHARMA2

SOLID PHASE SYNTHESIS OF BENZO[D]THIAZOL-2-YLCARBAMODITHIOATES AND THEIR EVALUATION AS POTENTIAL ANTIFUNGALS
SUMAN R GHATELWAL1, ANJALI SIDHU1, KHUSHBU GUMBER1 AND VINEET K SHARMA2
1DEPARTMENT OF CHEMISTRY, PUNJAB AGRICULTURAL UNIVERSITY, LUDHIANA, 141001, INDIA
2DEPARTMENT OF PLANT PATHOLOGY, PUNJAB AGRICULTURAL UNIVERSITY, LUDHIANA, 141001, INDIA.
Corresponding author email: khushbugumber8@gmail.com

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Published

2017-07-01

How to Cite

KHUSHBU GUMBER1 AND VINEET K SHARMA2, S. R. G. A. S. (2017). 4. SOLID PHASE SYNTHESIS OF BENZO[D]THIAZOL-2-YLCARBAMODITHIOATES AND THEIR EVALUATION AS POTENTIAL ANTIFUNGALS by SUMAN R GHATELWAL1, ANJALI SIDHU1, KHUSHBU GUMBER1 AND VINEET K SHARMA2Benzo[d]thiazol-2-amines (1 and 2) were synthesized by bromocyclizati. INTERNATIONAL RESEARCH JOURNAL OF CHEMISTRY, 18, 30 to 37. Retrieved from https://petsd.org/ojsnov/index.php/irjc/article/view/118

Issue

Vol. 18 (2017): JULY 2017 .... ISSN 2321 – 2845 (Online) ... ISSN 2321 – 3299 (Print)

Section

Research Paper

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