12.SODIUM FLUORIDE INDUCED ALTERATION IN DEHYDROGENASE AND ACETYL CHOLINESTERASE ACTIVITY IN VITAL TISSUES OF POECILIA RETICULATA PETERS By H. U. SHINGADIA AND E. R. AGHARIA

Authors

  • H. U. SHINGADIA AND E. R. AGHARIA

Abstract

Fluoride within permissible limits prevents dental caries, osteoporosis and osteosclerosis but intake of fluoride above standard limit (1.5 mg/L WHO 1996) causes dental, skeletal or non-skeletal Fluorosis distressing the health. The exposure of the larvivorous fish Poecilia reticulata Peters to sublethal concentrations of sodium fluoride (5.75 ppm, 7.18 ppm and 9.58 ppm) for a period of sixty days revealed stress of toxicant on respiratory metabolism of the animal altering Succinic dehydrogenase & Lactate dehydrogenase enzymes involved in carbohydrate metabolism. The decrease in concentrations of both SDH (P ? 0.05) & LDH (P ? 0.05) enzymes might have led to metabolic shift from aerobic to anaerobic mode of respiration during the toxic phase of fluoride induced stress. The reduction in the activity of dehydrogenase system showed impairment of oxidative metabolism. Fluoride also induced intense effect on the enzyme acetyl cholinesterase that plays imperative role in the transmission of nerve impulse. The decreased concentration of enzyme acetyl cholinesterase (P ? 0.05) might be due to the fact that excessive fluoride might have caused damage the central nervous system. Activities of dehydrogenase & Acetyl cholinesterase were observed to be fluoride concentration & time depended. Assessment of biochemical parameters in damaged fish organs can thus be used as a diagnostic tool to assess toxicant induced stress and wellbeing of the organism.
KEY WORD: Succinic dehydrogenase, Lactate dehydrogenase, Acetyl cholinesterase, P. reticulate Peters.

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Author Biography

H. U. SHINGADIA AND E. R. AGHARIA

SODIUM FLUORIDE INDUCED ALTERATION IN DEHYDROGENASE AND ACETYL CHOLINESTERASE ACTIVITY IN VITAL TISSUES OF
POECILIA RETICULATA PETERS
H. U. SHINGADIA AND E. R. AGHARIA
DEPARTMENT OF ZOOLOGY AND
DEPARTMENT OF CHEMISTRY
S.V.K.M’S MITHIBAI COLLEGE OF ARTS,
CHAUHAN INSTITUTE OF SCIENCE & A. J. COLLEGE OF COMMERCE & ECONOMICS, VILE PARLE (WEST) MUMBAI 400 056 MAHARASHTRA INDIA.
Corresponding author’s e-mail: hiteshshingadia@yahoo.co.in, mhea22@rediffmail.com

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Published

2013-11-01

How to Cite

AND E. R. AGHARIA, H. U. S. (2013). 12.SODIUM FLUORIDE INDUCED ALTERATION IN DEHYDROGENASE AND ACETYL CHOLINESTERASE ACTIVITY IN VITAL TISSUES OF POECILIA RETICULATA PETERS By H. U. SHINGADIA AND E. R. AGHARIA. LIFE SCIENCES LEAFLETS, 45, 122 to 128. Retrieved from https://petsd.org/ojs/index.php/lifesciencesleaflets/article/view/601

Issue

Vol. 45 (2013): NOVEMBER, 2013.....ISSN 0976 - 1098(On Line) ISSN 2277 - 4297(Print)

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Articles

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