Recent advances in microwave assisted synthesis of biological active 2-aminothiazole-schiff bases and their metal chelates

Abstract

The pharmacophore 2-aminothiazole is an interesting part of pharmaceutical chemistry because it makes it easier to synthesize molecules that have a wide range of biological activities. Schiff base derivatives additionally possess a significant role in medication evolution. Schiff bases with an imine or azomethine (-C=N-) functional group serve as useful pharmacophores for the design and development of various types of bioactive chemicals. A microwave aids in the condensation of an amine with carbonyl compounds to produce Schiff base metal complexes. This method is rapid, efficient, eco-friendly, and clean. Environmental friendliness, a straightforward work-up procedure, quick reaction times, non-hazardousness, and superior yields are only a few benefits of the unusual technology. In man-made organic chemistry, the microwave-aided approach has emerged as a novel and quickly expanding field. Reactions that often take many hours to complete at reflux temperature under traditional settings can frequently be finished in a microwave oven in a matter of minutes or even seconds. According to the evidence on biological activity, certain metal complexes work better than the free ligand. Because of their many pharmacological uses as antifungal, antibacterial, antitubercular, antiviral, antimalarial, antidiabetic, anticancer, antioxidant, antidiuretic, anti-inflammatory, and antipyretic, medicinal chemists focus on novel chemotherapeutic Schiff bases and their metal complexes. The green synthesis and biological uses of Schiff bases, including 2-aminothiazoles and their metal complex using microwave irradiation, are covered in this review.

KEYWORDS: green chemistry, thiazole heterocycle, Schiff bases, metal complexes, microwave irradiation, biological activity.