Synthesis and In-vitro glucosidase inhibitory activity of some novel indole derivatives

Authors

  • Ashvini Vilas Joshi Ashvini Vilas Joshi 9527330471
  • Vaibhav. S. Wagh Vaibhav Wagh N N SATTHA COLLEGE OF PHARMACY AHMEDNAGAR
  • Kunal Raut N N SATTHA COLLEGE OF PHARMACY AHMEDNAGAR

Abstract

The objective of this paper is to focus on developing new entities of the heterocyclic molecule for its in-vitro inhibitory activities of glucosidase enzyme and the preparation and separation of new entities of the indole derivatives.

Most of the indole derivatives are synthesized from the Phenyl Hydrazine and Ketone as a precursor. The prepared molecules were thoroughly tested for qualitative and quantitative analysis such as preliminary test, melting points, boiling points, Thin Layer Chromatography, Infra-Red spectroscopy, proton NMR spectroscopy, and element are determined by confirmation of final structure. The Indole ring compounds were analyzed and evaluated for glucosidase inhibitory activity by the In-vitro studies through the glucosidase inhibitory activity assay. Acarbose was used as a standard drug. The present data of in-vitro studies have led to the probable conclusion that the new Indole analogs would be taken as efficient glucosidase inhibitory activity.

Keyword: In vitro-glycosidase inhibitory activity, ketone, novel indole derivative, phenylhydrazine

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Author Biographies

Vaibhav. S. Wagh Vaibhav Wagh, N N SATTHA COLLEGE OF PHARMACY AHMEDNAGAR

ASSISTANT PROFRSSOR,

DEPARMENT OF PHARMACEUTICAL CHEMISTRY

N N SATTHA COLLEGE OF PHARMACY AHMEDNAGAR

Kunal Raut, N N SATTHA COLLEGE OF PHARMACY AHMEDNAGAR

ASSISTANT PROFESSOR,

DEPARTMENT OF PHARMACEUTICAL CHEMISTRY

N N SATTHA COLLEGE OF PHARMACY AHMEDNAGAR

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Published

2022-12-01

How to Cite

Ashvini Vilas Joshi, A. V. J., Vaibhav Wagh, V. S. W., & Kunal Raut. (2022). Synthesis and In-vitro glucosidase inhibitory activity of some novel indole derivatives. INTERNATIONAL RESEARCH JOURNAL OF CHEMISTRY, 37, 1–15. Retrieved from https://petsd.org/ojs/index.php/irjc/article/view/1656