3. THE EFFECT OF LONG TERM HIGH FRUCTOSE HIGH FAT (HFHF) DIET ON BODY WEIGHT, GLUCOSE HOMEOSTASIS AND LIPID PROFILE IN ADULT WNIN RATS by K. SIVA KESAVARAO1, T. RAGHAVA RAO2 AND P. SURYANARAYANA1#

  • SIVA KESAVARAO
Keywords: Effect, High Fructose High Fat (HFHF), Body weight, Glucose homeostasis, Lipid profile, WNIN rats.

Abstract

This study was aimed at investigating the effect of high-fructose high-fat (HFHF) diet for longer duration (10 months) on body weight, glucose homeostasis and lipid profile in WNIN rats. Two months old male Wistar NIN (WNIN) rats were maintained either on AIN-93M diet alone (control group) or high fructose (32%) with high fat (24%) contains AIN- 93 diet (HFHF group) to WNIN rats developed insulin resistance associated pre-diabetes at 3 months, maintained pre-diabetes over a period of 10 months. Body weight after one month of feeding show that significantly higher in rats fed HFHF diet compared to rats fed AIN-93 diet. Rats fed HFHF diet exhibited significantly higher plasma triglycerides and significantly lowered HDL levels at the end of the experiment, but total cholesterol levels marginally reduced and LDL levels slightly higher in HFHF fed rats compared to control. These results suggest that a HFHF diet ideal for obesity and consequence of complications.

Author Biography

SIVA KESAVARAO

SIVA KESAVARAO1, T. RAGHAVA RAO2 AND SURYANARAYANA1#
1 LIPID CHEMISTRY DIVISION, NATIONAL INSTITUTE OF NUTRITION, HYDERABAD.
2 BIOCHEMISTRY DIVISION, ANDHRA UNIVERSITY, VISAKHAPATNAM, INDIA.
Corresponding author’s e-mail: kskraok@gmail.com

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Published
2017-06-29