PROTEASES AND PROTEASE INHIBITORS INTERACTION: DEFENCE STRATEGY AGAINST

  • R.S.DHANDE 1 N.J.CHIKHALE 2 PROTEASES AND PROTEASE INHIBITORS INTERACTION: DEFENCE STRATEGY AGAINST R.S.DHANDE 1 & N.J.CHIKHALE 2 1 DEPARTMENT OF BOTANY, SHRI SHIVAJI COLLEGE, AKOT. DIST. AKOLA (M.S.) INDIA 2 SHRI SHIVAJI AGRICULTURE COLLEGE, AMRAVATI (M.S.) INDIA. Corresponding author’s e-mail: ravi_dhande2005@yahoo.co.in

Abstract

ABSTRACT:
An increase in crop yield, its management and preservation are among the main
challenges standing before the human population that exceed 10 billion by the
mid of 21 st  century.  Every year, considerable agricultural losses occur due to
repeated practices of cultivation of large genetically similar populations.  Such
cultivation practices favors incidence of more insect pests (Hilder and Boulter,
1999;  Oerke  et  al.,  1994;  Smith,  1999).  To  solve  these  problems,  current
approaches  rely  on  use  of  synthetic  chemicals  like  fertilizers,  insecticides,
herbicides,  fungicides  etc.  But  this  exerts  excessively  high  pressure  on
environment  and  destabilizes  the  ecological  balance.  The  traditional  pest
control method involves the use of conventional pesticides, most of which are
non-specific and wipe out the entire community, pollutes the agro-ecosystem,
and  increases  the  cost  of  production.  The  emergence  of  gene  transfer
technology  has  solved  some  problems  regarding  overuse  of  chemical
pesticides.  The  delta  endotoxin  encoding  gene  from  Bacillus  thuringiensis,  a
gram positive soil borne bacteria transferred in crops has given little relief from
coleopterans and lepidopterans attack.  Whereas, the insects belonging to these
orders like Helicoverpa Sps. have developed resistance against Bt toxins. The
other approach takes advantage of use of plant genes encoding defense proteins
like protease inhibitors which is more appealing, simpler and safer (Dunaevsky
et.  al.,  2005).  Proteinase  inhibitors  (PIs)  are  naturally  occurring  proteins  in
living organisms and are able to inhibit & control the activity of proteases. PIs
act  on  an  active  site  of  digestive  proteolytic  enzymes  and  form  a  stable
complex  unlike  enzyme-substrate  or  enzyme-product  weak  complexes  which dissociates in short span of time (Oliva et. al., 2010). The activity of PI is to control proteolysis in cells and
its components responsible for biochemical and physiological process by blocking, altering or preventing
access to the enzyme active site. According to Broadway and Duffey (1986), the reduction in growth rate
of insects is due to the hyperproduction of proteinases to compensate for loss of activity, which in turn led
to the depletion of essential amino acids. Like other competitive PIs, cystatins form a light complex with
target proteases to cause inhibition and interfere with dietary protein digestion in herbivores (Arai et. al.,
2002). Chye et. al., (2006); Macedo et. al., (2004) and Ramos et. al., (2008) have demonstrated action of
inhibitor proteins on insect gut proteases using artificial diets and invitro inhibition assays.
KEY WORDS: Black kite, Trachea, Gross Anatomy.

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How to Cite
N.J.CHIKHALE 2, R.S.DHANDE 1. PROTEASES AND PROTEASE INHIBITORS INTERACTION: DEFENCE STRATEGY AGAINST. LIFE SCIENCES LEAFLETS, [S.l.], v. 59, dec. 2014. ISSN 0976-1098. Available at: <http://petsd.org/ojs/index.php/lifesciencesleaflets/article/view/222>. Date accessed: 28 june 2017.

Keywords

Black kite, Trachea, Gross Anatomy.