1. RNA EDITING IN DISEASES by ARIJIT SHOME1 AND RATANTI SARKHEL2
RNA editing is one of the post-transcriptional RNA processes. RNA editing generates RNA and protein diversity in eukaryotes and results in specific amino acid substitutions, deletions, and changes in gene expression levels. Adenosine-to-inosine RNA editing represents the most important class of editing in human and affects function of many genes. The importance of balancing RNA modification levels across time and space is becoming increasingly evident. RNA editing has been observed in some tRNA, rRNA, mRNA or miRNA molecules of eukaryotes and their viruses, archaea and prokaryotes. RNA editing occurs in the cell nucleus and cytosol, as well as within mitochondria and plastids.