INTERNATIONAL RESEARCH JOURNAL OF CHEMISTRY <ul> <li class="show"><span style="text-decoration: underline;"><strong>ISSN 2321-2845 (Online) ISSN 2321-3299 (Print)</strong></span></li> <li class="show">INTERNATIONAL RESEARCH JOURNAL OF CHEMISTRY is an international open access online &amp; print&nbsp; journal, world wide abstract listed, published quarterly&nbsp; with ISSN, Free- membership, download and access. This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.</li> </ul> <p><!-- Google Tag Manager --></p> <p>&nbsp;</p> en-US (DR N K PATEL) Tue, 01 Jan 2019 00:00:00 +0000 OJS 60 1. COMPARATIVE STUDY OF CHEMICAL VARIANTS IN IN VITRO AND WILD GROWN ROOT EXTRACTS OF VALLERIANA WALLICHI DC. by ABIGAIL H ZIMOMI1, KALPANA KUKREJA1, RONALD DEBBARMA2, NEELAM KHARE2 AND SANDEEP ROUT2 <p>The laboratory experiment was carried out during May-August 2013 at Department of Forestry, in Doon (PG) College of Agriculture Science and Technology, Dehradun (Uttarakhand), for comparative study on varied phyto-chemicals present among different extracts of <em>in vitro</em> and wild grown <em>Valeriana wallichi</em>. Extract yield per cent was found highest with W<sub>DW</sub> (25%). Phytochemical screening of <em>Valeriana </em>extracts indicated the presence of different classes of secondary metabolites. Proteins, amino acids, flavonoids, betacyanins, tannins, coumarins, terpenoids and saponins were present in all the tested extracts i.e I<sub>M</sub>, W<sub>M</sub>, I<sub>DW</sub> and W<sub>DW</sub>. Phenols, anthocyanins and carbohydrates are present only in <em>in vitro</em> extracts (I<sub>M</sub> and I<sub>DW</sub>).<sub>&nbsp; </sub>However, glycosides, quinones, and, gums and mucilages were absent. Flavonoids were analyzed quantitatively in <em>Valeriana </em>extracts. Flavonoid content was found higher in <em>in vitro</em> root extracts (I<sub>M</sub> and I<sub>DW</sub>) as compared to wild root extracts (W<sub>M</sub> and W<sub>DW</sub>). The results revealed that I<sub>DW </sub>extract has highest (51.7 mg/g) flavonoid and W<sub>M</sub> has lowest flavonoid content i.e. 13.5 mg/g. The analysis of phytochemicals was also performed using the gas chromatography-mass spectroscopy (GC-MS) method. GC-MS chromatogram showed that total of 110 and 126 chemical compounds were identified with I<sub>M</sub> and W<sub>M</sub> respectively. Total of thirteen major compounds were found in <em>in vitro </em>and wild grown root extracts. Valepotriate i.e. Isovaleric acid (W<sub>M </sub>- 3.12 % and I<sub>M</sub> - 1.56%) and valerenic acid (I<sub>M </sub>- 7.74% and W<sub>M </sub>6.56%) were observed. Another compound, valerana was seen in very small amount (I<sub>M</sub> - 0.36% and W<sub>M</sub> - 0.20%). Viridiflorol: W<sub>M</sub> (15.41%) and I<sub>M</sub> (3.45%) were found. However, viridiflorene was present only in W<sub>M</sub> (0.36%) extract. Among fatty acids, palmitic acid was seen in I<sub>M</sub> - 11.64% and W<sub>M</sub> - 2.35%.</p> ABIGAIL H ZIMOMI1, KALPANA KUKREJA1, RONALD DEBBARMA2, NEELAM KHARE2 AND SANDEEP ROUT2 ##submission.copyrightStatement## Tue, 01 Jan 2019 00:00:00 +0000 2. POTENTIAL FOR IMPROVED GLUCOSE HOMEOSTASIS WITH DIETARY CINNAMON IN SD RATS WITH PRE-DIABETES by K. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1. <p>This study was aimed at investigating the beneficial effects of cinnamon (CN) on altered glucose homeostasis in neonatal streptozotocin (nSTZ) induced pre-diabetic rat model. Two-day-old male Sprague–Dawley (SD) rat pups received a single intraperitoneal STZ injection (90 mg/kg body weight) dissolved in 0.1 M citrate buffer (pH 4.5). Control pups (n = 8) received the vehicle alone. All rats were maintained on an AIN-93G/M diet in individual cages and a subset of pre-diabetic animals received 3% CN in the AIN-93 diet. The majority of nSTZ-treated rats exhibited impaired glucose tolerance (IGT) or pre-diabetes 2 months following STZ injection and this was maintained up to 10 months. Pre-diabetes induced blood glucose, plasma insulin and plasma glucose levels were partially prevented by cinnamon through its hypoglycemic potential.</p> K. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1*. ##submission.copyrightStatement## Tue, 01 Jan 2019 00:00:00 +0000