THE IMPORTANCE OF A “NEGATOME” DATABASE FOR ORGANIC CHEMISTRY REACTIONS, A CASE STUDY: REACTION OF BROMINATION OF PALMITOYLETHANOLAMIDE

  • RAFFAELE CONTE

Abstract

The failure of organic chemistry reactions is a problem that affects the research. In some cases, however, setbacks could be avoided through better communication between laboratories. Aim of this paper is to promote the discussion on the necessity to set a “Negatome†database for the unsuccessful interactions through the example of the reaction of bromination of Palmitoylethanolamide with Triphenylphosphine (PPh3) and N-bromosuccinimide (NBS),  that is considered to be thermodynamically favored but that not occurs in the conditions described in this publication.

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RESEARCH PAPER