SYNTHESIS AND BIOLOGICAL STUDY OF 5-(((4,5-DIPHENYL-4H-1,2,4-TRIAZOL-3-YL)THIO)METHYL)QUINOLIN-8-OL AND ITS METAL COMPLEXES

  • VIPUL PRAJAPATI JALPA LIMBACHIA VIPUL PRAJAPATI* AND JALPA LIMBACHIA SHETH MOTILAL NYALCHAND SCIENCE COLLEGE, HNGU, PATAN, GUJARAT, INDIA. Email: vipul_hely@yahoo.com, jil1611@yahoo.com
Keywords: 8-Hydroxyquinoline, Thiol, 1, 2, 4-Triazole

Abstract

A novel ligand namely  compound of 5-(((4,5-diphenyl-4h-1,2,4-triazol-3-yl)thio)methyl)quinolin-8-ol (THQ), derived in a good yield by condensation of from 4,5-diphenyl-4H-1,2,4-triazole-3-thiol with 5-chloromethyl-8-quinolinol (HQ). It was characterized by  elemental analysis and spectral analysis. Various transition metal complexes of 5-(((4,5-diphenyl-4h-1,2,4-triazol-3-yl)thio)methyl)quinolin-8-ol(THQ) metal ions were prepared by treatment of THQ and metal salt of stoichiometric ratio. All the resultant metal complexes were characterized by metal ligand ratio, spectral and magnetic properties. All the samples i.e. THQ and its complexes were screened for their antimicrobial activity.

KEY WORD: 8-Hydroxyquinoline, Thiol, 1,2,4-Triazole

References

X.H. Ouyang, G.R. Wang, H.P. Zeng, W.M. Zhang, J. Li, J. Organomet. Chem. 694(2009) 3511.
2. J.A. Gonzalez-Vera, E. Lukovic, B. Imperiali, J. Org. Chem. 74 (2009) 7309.
3. L.H. Li, B. Xu, Tetrahedron 64 (2008) 10986.
4. B. Himmi, J.P. Joly, F. Hlimi, M. Soufiaoui, S. Kitane, A. Bahloul, A. Eddaif, A. Sebban, J. Heterocycl. Chem. 45 (2008) 1023.
5. X.H. Ouyang, H.P. Zeng, Y. Xie, Chin. J. Org. Chem. 27 (2007) 402.
6. A. Mishra, P.K. Nayak, N. Periasamy, Tetrahedron Lett. 45 (2004) 6265.
7. K.G. Daniel, D.J. Kuhn, A. Kazi, Q.P. Dou, Curr. Cancer Drug Targets 5 (2005) 529.
8. Chai B, Qian X, Cao S, Liu H, Song G (2003) ARKIVOC ii:141–145s.
9. Shaker RM (2006) ARKIVOC ix:59–112.
10. Al-Khawas MS, Hazaa BAA, Al-Din AS (1979) Sci Pharm 47:314–320.
11. Kurse LI, Finkelestein JA (1990) Eur Pat App Ep-395, 505 (Cl. C07 D401/60) Chem
Abst (1990)113, 115311w.
12. Hullman, JW, Wu MJ, Lu J, J. Org. Chem. 1998: 63; 4510.
13. Stillings MR, Welbourn AP, Walter D, J. Med. Chem. 1986: 29; 2280.
14. Ibrahim A, Rahman, A.; Abdu, E.; Edity, B. Collect. Czech. Chem. Commun. 1991: 56; 1749.
15. Heindel ND, Reid JR. J Heterocycl Chem, 1980:17.
16. V. P. Prajapati, J. R. Limbachia, ISST Journal of Applied Chemistry, Vol. 4 No. 2, (JulyDecember 2013), p.p. 25-28
17. K.M. Daoud, A.W. Al-Obaydi, National Journal of Chemistry,2008, Volume 31, 531- 542.
18. K.K. Oza, D.H. Jani, H.S. Patel, Appl. Organomet. Chem. 25 (2011) 154.
19. F. A. Cot t on, G. Wi l ki nson, Advanced Inorganic Chemistry, 5th edn, Wiley Interscience, New York,1988.
20. B. N. Figgis, The magnetochemisty of complxes in modern coordination chemistry, Interscience, New yourk (1960).
Published
2015-03-31