2. POTENTIAL FOR IMPROVED GLUCOSE HOMEOSTASIS WITH DIETARY CINNAMON IN SD RATS WITH PRE-DIABETES by K. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1.

  • K. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1*.
Keywords: Pre-diabetes, Diabetic retinopathy, Cinnamon, Neonatal Streptozotocin.

Abstract

This study was aimed at investigating the beneficial effects of cinnamon (CN) on altered glucose homeostasis in neonatal streptozotocin (nSTZ) induced pre-diabetic rat model. Two-day-old male Sprague–Dawley (SD) rat pups received a single intraperitoneal STZ injection (90 mg/kg body weight) dissolved in 0.1 M citrate buffer (pH 4.5). Control pups (n = 8) received the vehicle alone. All rats were maintained on an AIN-93G/M diet in individual cages and a subset of pre-diabetic animals received 3% CN in the AIN-93 diet. The majority of nSTZ-treated rats exhibited impaired glucose tolerance (IGT) or pre-diabetes 2 months following STZ injection and this was maintained up to 10 months. Pre-diabetes induced blood glucose, plasma insulin and plasma glucose levels were partially prevented by cinnamon through its hypoglycemic potential.

Author Biography

K. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1*.
  1. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1*.

1LIPID CHEMISTRY DIVISION, NATIONAL INSTITUTE OF NUTRITION, HYDERABAD, TELANGANA, INDIA.            

 2 ANDHRA UNIVERSITY, BIOCHEMISTRY DIVISION, VISAKHAPATNAM.

Corresponding author email:  kskraok@gmail.com

Published
2019-01-01
How to Cite
P. SURYANARAYANA1*.K. S. K. T. R. A. (2019). 2. POTENTIAL FOR IMPROVED GLUCOSE HOMEOSTASIS WITH DIETARY CINNAMON IN SD RATS WITH PRE-DIABETES by K. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1. INTERNATIONAL RESEARCH JOURNAL OF CHEMISTRY, 24, 15 TO 22. Retrieved from http://petsd.org/ojs/index.php/irjc/article/view/1373