2. POTENTIAL FOR IMPROVED GLUCOSE HOMEOSTASIS WITH DIETARY CINNAMON IN SD RATS WITH PRE-DIABETES by K. SIVA KESAVARAO1, T. RAGHAVARAO2 AND P. SURYANARAYANA1.
This study was aimed at investigating the beneficial effects of cinnamon (CN) on altered glucose homeostasis in neonatal streptozotocin (nSTZ) induced pre-diabetic rat model. Two-day-old male Sprague–Dawley (SD) rat pups received a single intraperitoneal STZ injection (90 mg/kg body weight) dissolved in 0.1 M citrate buffer (pH 4.5). Control pups (n = 8) received the vehicle alone. All rats were maintained on an AIN-93G/M diet in individual cages and a subset of pre-diabetic animals received 3% CN in the AIN-93 diet. The majority of nSTZ-treated rats exhibited impaired glucose tolerance (IGT) or pre-diabetes 2 months following STZ injection and this was maintained up to 10 months. Pre-diabetes induced blood glucose, plasma insulin and plasma glucose levels were partially prevented by cinnamon through its hypoglycemic potential.